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Historically, women didn’t have a reliable method of knowing if they were pregnant without going to the doctor. It wasn’t until the invention of the first self-pregnancy test in 1976 that women could confirm that they were pregnant without visiting a hospital.

But despite the advancements in the home self- pregnancy testing kit that let women know they are pregnant, there’s still a lot of mystery about women’s menstrual cycle.

Women may have delayed or missed periods, but still have a negative pregnancy test. In such situations, women wonder what’s going on. Are they pregnant? Or is something wrong?

Below are some of the reasons that might cause periods to be missed with a negative pregnancy test

It’s very rare, but sometimes an ectopic pregnancy can show up as negative on a pregnancy test. This also might happen in 3% of ectopic pregnancies.

Ectopic pregnancy

You must seek medical attention if your pregnancy test is negative and you have these symptoms:

  • Vaginal bleeding or spotting.
  • Lightheadedness or dizziness
  • severe pain low in your abdomen or on one side
  • Vomiting and nausea
  • Low hormone levels

If you’re trying to get pregnant and the test results are still negative but with a missed period, there’s good news: You may still be pregnant. Sometimes, levels of the pregnancy hormones Human Chorionic Gonadotropin (HCG) early in pregnancy are not yet high enough for a home pregnancy test to detect in the urine.

Women’s menstrual cycle can vary widely, so if you conceived later in your cycle, your hormone levels may not be high enough at the time of your missed period.

There can be as much as a 13-day difference in when ovulation occurs, meaning that you may think you are 4 weeks pregnant when you’re only two weeks.

If you think you may be pregnant after a missed period but got a negative result on your pregnancy test, wait a few days. Then retest. If you continue to miss your period, be sure to talk to your doctor to rule out any medical complications.

  • Breastfeeding

Breastfeeding may also cause some irregularities in your cycle. Even after your period return after giving birth, it may take some time before your cycle goes back to normal.

Breastfeeding is also unpredictable month to month. As babies grow, their feedings may change. For example, if your baby goes through a growth spurt and suddenly increases the frequency of night feedings, it may interfere with your cycle.

  • Life style factors

Several lifestyle factors can interrupt your menstrual cycle. For example, stress can delay your period. Poor nutrition can as well affect your cycle. Your cycle can also  fluctuate if you drink too much coffee.

Sudden lifestyle changes, such as intense exercise or working the overnight shift on your job, can also cause your period to be irregular.

  • Medical conditions

Medical conditions such as polycystic ovary syndrome (PCOS) or problems with the thyroid may cause women to have highly irregular cycles and missed periods. Some women may have very light periods, some may have very heavy periods, and some may skip periods altogether. Menopause for women typically begins around age 50. In some women, however, it can start prematurely, before the age of 40. It’s different for everyone. If you have missed your period for over 90 days and are not pregnant, talk to your doctor about getting tested for any underlying medical conditions

  • On going medication

Birth control pills (BPC) can also cause irregularities in your cycle. Other types of medications may lead to a missed period, as well. For example, blood pressure drugs or allergy medications can throw off your cycle.