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Mifepristone, also known as RU-486 is a medication typically used in combination with misoprostol to bring about an abortion during pregnancy. It is also effective during the second trimester of pregnancy. Effectiveness should be varified in 2 weeks after use.

Mifepristone is an antiprogestogen, it works by blocking the effect of progestrone, making the cervix easier to open and promoting contraction of the uterus when exposed to misoprostol.